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Researcher DataBase - Personal Information : TOKUMOTO Toshinobu

TOKUMOTO Toshinobu
Professor
College of Science - Division of Biological Science
Graduate School of Science and Technology,Research Division - Research of Integrated Bioscience
Faculty of Science - Department of Biological Science Graduate School of Integrated Science and Technology Department of Science - Biological Sciences Course

tokumoto.toshinobu@@@shizuoka.ac.jp
image-profile
Last updated : 2024/04/16 2:05:06

Basic information on teaching staff

【Degrees earned】
Doctor of Science  The Graduate University for Advanced Studies   1994/3
【research themes】
Analysis of molecular mechanism in oocyte maturation (meiotic cell cycle)
Non-genomic actions of steroids
【Research Keyword】
oocyte maturation, membrane steroid receptors, proteasome, ovulation, sex change
【Research Seeds】
[1]. ステロイド膜受容体の機能解明と創薬に向けた研究 ( 2019(FY) - ) [Category] 5. バイオ・ライフサイエンス [URL]
 

Research information

【Papers, etc.】
[1]. Establishment of a graphene quantum dot (GQD) based steroid binding assay for the nuclear progesterone receptor (Pgr)
Biochemistry and Biophysics Reports 38/ 1-6 101691 (2024) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Md. Forhad Hossain, Shakhawat Hossain, Md. Maisum Sarwar Jyoti, Yuki Omori, Saokat Ahamed and Toshinobu Tokumoto [DOI]
[2]. Evidence of binding between diethylstilbestrol (DES) and the goldfish (Carassius auratus) membrane progesterone receptor α
Toxicology Mechanisms and Methods / - (2024) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Md. Forhad Hossain, Umme Habiba Mustary, Toshinobu Tokumoto [DOI]
[3]. Establishment of a steroid binding assay for goldfish membrane progesterone receptor (mPR) by coupling with graphene quantum dots (GQDs)
Fish Physiology and Biochemistry / - (2024) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Md. Forhad Hossain, Shakhawat Hossain, Md. Maisum Sarwar Jyoti, Yuki Omori, Toshinobu Tokumoto [DOI]
[4]. Zebrafish prss59.1 is involved in chorion development
General and Comparative Endocrinology / - (2024) [Refereed] refereed [Internationally co-authored papers] internationally co-authored paper
[Lead author or co-author] author
[Author] Md. Rezanujjaman, Theeranukul Pachoensuk, Md. Forhad Hossain, Md. Maisum Sarwar Jyoti, Md. Rubel Rana, Eisei Tsutsumi, Takumi Mouri, Maria Bramastri Susilo, Klangnurak Wanlada, Chihiro Yamamoto, Md. Hasan Ali, Toshinobu Tokumoto [DOI]
[5]. The antagonistic activity of Padina arborescens extracts on mPRα
Natural Product Research 37/11 1872-1876 (2023) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Mrityunjoy Acharjee, Md. Hasan Ali, Md. Maisum Sarwar Jyoti, Md. Rezanujjaman, Md. Maksudul Hassan, Md. Rubel Rana, Md. Forhad Hossain, Shinya Kodani and Toshinobu Tokumoto [DOI]
【Books, etc.】
[1]. Advances in Animal Science and Zoology
Nova Science Publishers (2023)
[Book type]book(research)
[Sole author, co-author, or author and editor] contributor
[Author]Md. Forhad Hossain, Toshinobu Tokumoto [Range] Is the Decrease in cAMP Concentration in Oocytes Really a Trigger for Oocyte Maturation Induction? - From the Perspective of Fish Research [Total page number] 21 [REP page number] 127-147
[2]. Understanding neuroendocrine regulatory pathways of sexual behavior in teleosts
Aquaculture and Fisheries (2023)
[Book type]book(research)
[Sole author, co-author, or author and editor] joint work
[Author]Saokat Ahamed and Toshinobu Tokumoto [REP page number] 1-8
[3]. Morphological and physiological studies on sex change in tropical fish: Sexual plasticity of the ovaries of hermaphroditic and gonochoristic fish
The Japanese Coral Reef Society (2022)
[Book type]other
[Sole author, co-author, or author and editor] joint work
[Author]Masaru Nakamura, Ryo Nozu, Shigeo Nakamura, Mikihiko Higa, Ramji K Bhandari, Yasuhisa Kobayashi, Ryo Horiguchi, Toru Komatsu, Yutaka Kojima, Ryosuke Murata, Kiyoshi Soyano, Satoshi Ogawa, Toshiaki Hirai, Hajime Matsubara, Toshinobu Tokumoto, Tohru Kobayashi, Hirohiko Kagawa, Shinji Adachi, Kohei Yamauchi, and Yoshitaka Nagahama [Total page number] 13
[Notes] Galaxea, Journal of Coral Reef Studies誌の総説
[4]. Membrane progestin receptor, a key mediator of final oocyte maturation in fish
NOVA Science Publishers Inc., USA (2018)
[Book type]book(research)
[Sole author, co-author, or author and editor] contributor
[Author]Toshinobu Tokumoto [Range] 423-440 [Total page number] 468 [REP page number] 423-440
[5].
(2016)
[Book type]book(research)
[Sole author, co-author, or author and editor] joint work
[Author]徳元 俊伸 [Total page number] 267 [REP page number] 199-214
【Academic conference/research presentations】
[1]. Phenotypic analysis of gene knock-out strains of highly upregulated genes during ovulation in zebrafish
International Symposium on Reproductive Physiology of Fish 12th ISRPF (2023/5/16) other
[Presenter]Toshinobu Tokumoto
[Notes] Crete, Olympia, Greece
[2]. Expression and purification of human membrane estrogen receptor (hmER) and establishment of high throughput assays using GQDs
第46回日本比較内分泌学会大会及びシンポジウム (2022/10/30) other
[URL of the repository, etc.]
[3]. ゲノム編集による新たなマウステラトーマ形成原因遺伝子の同定
静岡実験動物研究会令和4年度研究発表会 (2022/10/28) other
[Presenter]大浦 薫、関 駿介, Abdullah AN Naser, 宮嵜岳大, 徳元 俊伸
[4]. ゼブラフィッシュにおけるStmは卵膜上のノブ型構造及び卵膜孔の形成に関与する
日本動物学会 第93回早稲田大会 (2022/9/9) other
[Presenter]毛利 匠, Theeranukul Pachoensuk, Md Rezanujjaman, Klangnurak Wanlada, 山本 千尋,徳元 俊伸
[5]. ゼブラフィッシュにおける排卵関連遺伝子 prss59.1 の機能解析
日本動物学会 第93回早稲田大会 (2022/9/9) other
[Presenter]堤 瑛誠,Md Rezanujjaman, Md. Forhad Hossain,毛利 匠, Maria Bramastri Susilo, Md. Hasan Ali,山本 千尋,徳元 俊伸
【Joint or funded research】
[1]. funded (public) 構造活性相関に基づくステロイド膜受容体作用物質群の同定
leader ( 2009/4 ~ 2010/3 )
[Partners] 環境省
[Notes] ExTEND2005フィージビリティースタディー
[2]. funded (public) ステロイド膜受容体を標的とした化学物質の内分泌かく乱作用に関する研究
leader ( 2007/1 ~ 2009/3 )
[Partners] 環境省
[Notes] ExTEND2005フィージビリティースタディー
【Grants-in-aid for Scientific Research
[1]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2023/4 ~ 2026/3 ) Grant-in-Aid for Scientific Research (C) leader

[2]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2020/4 ~ 2023/3 ) Grant-in-Aid for Scientific Research (C) leader

[3]. ステロイド膜受容体の機能・構造解析を中心とした卵成熟・排卵誘導機構の解明 ( 2016/4 ~ 2019/3 ) Grant-in-Aid for Scientific Research (C) leader

[4]. モーリシャスサンゴ礁海水中に存在する天然ホルモン活性物質の同定 ( 2015/4 ~ 2018/3 ) Grant-in-Aid for Scientific Research (B) leader

[5]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2013/4 ~ 2016/3 ) Grant-in-Aid for Scientific Research (C) leader

【Research Grants & Projects(except for KAKENHI)】
[1]. ノンゲノミック反応を伝達する新規ステロイド膜受容体の構造と機能に関する研究 (2010/3 ) [Offer orgnization] 財団法人 内藤記念科学振興財団 [System name] 内藤記念科学奨励金
[2]. ステロイド膜受容体の構造と機能に関する研究 (2008/9 ) [Offer orgnization] 財団法人サントリー生物有機科学研究所 [System name] SUNBOR GRANT
[3]. 卵成熟過程におけるプロテアソームの機能の解析 (1995/9 ) [Offer orgnization] 実吉奨学会 [System name] 研究助成金
【Patents, etc.】
[1]. ステロイドホルモン膜受容体の精製方法 [Application Number] 特願2013-136980 (2013/6/28) [Patent Number] 特許第6516956号 (2019/4/26)
[Notes] 特開2015-10064
[2]. ステロイドホルモン膜受容体の精製方法 [Application Number] 特願2019-038776 (2013/6/28) [Patent Number] 特許第6516956号 (2020/11/16)
[3]. 内分泌撹乱性物質のスクリーニング方法 [Application Number] 特願2005-267894 (2005/9/15) [Patent Number] 特許第4528973号 (2010/6/18)
[4]. 内分泌撹乱性物質のスクリーニング方法 [Application Number] 特願2005-014006 (2005/1/21) [Patent Number] 特許第4501002号 (2010/4/30)
【Holding academic or research conferences, etc.】
[1]. Sustainability & Technology Workshop 2023 (2023/8)
[Role at conference, etc.] is leader [Site of conference, etc.] 静岡大学 理学部
[Notes] 国費留学生優先配置特別プログラム主催のワークショップ 2023年テーマ Bioscience for Sustainable Development: Advancing Knowledge and Action
[2]. 「ナノバイオロジー」への招待 日本動物学会 シンポジウム (2009/9)
[Role at conference, etc.] is leader [Site of conference, etc.] グランシップ 静岡市 
[Notes] 日本動物学会年次大会におけるシンポジウムの主催

Education related information

【Courses being taught this academic year】
[1]. Graduate School Course(Master's) 分子発生学特論 (2023(FY) - second semester )
[2]. Faculty Course 生物学Ⅱ (2023(FY) - second semester )
[3]. Faculty Course 動物発生学Ⅰ (2023(FY) - first semester )
[4]. Faculty Course 動物発生学Ⅱ (2023(FY) - first semester )
[5]. General Education Course 生命科学 (2023(FY) - second semester )
【Number of students advising】
2023(FY)
Number of undergraduate students(junior students) 3
Number of undergraduate students(senior students) 2
Number of master's course students : 7
Number of doctorate course students (main advisor) : 12 Number of doctorate course students (assistant advisor) : 2
2022(FY)
Number of undergraduate students(junior students) 4
Number of undergraduate students(senior students) 3
Number of master's course students : 6
Number of doctorate course students (main advisor) : 8 Number of doctorate course students (assistant advisor) : 2
2021(FY)
Number of undergraduate students(senior students) 4
Number of master's course students : 7
Number of doctorate course students (main advisor) : 7 Number of doctorate course students (assistant advisor) : 2
2020(FY)
Number of undergraduate students(senior students) 3
Number of master's course students : 6
Number of doctorate course students (main advisor) : 7 Number of doctorate course students (assistant advisor) : 2
2019(FY)
Number of undergraduate students(senior students) 3
Number of master's course students : 6
Number of doctorate course students (main advisor) : 5
【Prizes students you are advising won】
[1]. Best Presentation Award (2024/3)
[Name of student who received the prize] Md. Forhad Hossain (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 2024 The10th International Symposium toward the Future of Advanced Researches in Shizuoka University (ISFAR-SU2024)
[2]. The Best Presentation Award For Young Researchers (2023/9)
[Name of student who received the prize] Mohammad Maksudul Hassan (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 第20回Inter-Academia 2023
[3]. Best Presentation Award (2021/3)
[Name of student who received the prize] Theeranukul Pachoensuk (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 2021 The 7th International Symposium toward the Future of Advanced Researches in Shizuoka University (ISFAR-SU2021)
[4]. 優秀ポスター賞 (2019/3)
[Name of student who received the prize] 平野里沙 (Faculty of Science)
[Name of organization that offered the prize] 第20回静岡ライフサイエンスシンポジウム 静岡生命科学若手フォーラム主催
[5]. Best oral presentation (2019/1)
[Name of student who received the prize] Theeranukul Pachoensuk (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB2019)
【Information education-related information.】
[1]. 科学技術振興機構 中高生の科学部活動振興プログラム 「静岡県遠州南部地域のクマムシ調査」掛川西高校  (2013/4 - 2015/3 )
[2]. 理数学生応援プロジェクト 「主体性を伸ばす理数特別カリキュラムによる科学者養成プログラム」の申請、採択後の運営 (2009/1 - 2013/1 )

Contributions to society

【Seminar,Workshop, Event, etc.】
[1]. event ライフサイエンスワールド2016 (2016/5 - 2016/5 )
[Details] 「活性型・ヒト型プロゲステロン膜受容体(mPR)の大量合成技術を確立」という題目で新技術に関する講演、ブースの出展を行った。
[Notes] 東京ビッグサイトにて
[2]. event 第5回キャンパスフェスタin静岡 モデル魚類ゼブラフィッシュと触れ合おう (2015/11 )
[Details] 研究材料として世界的に用いられているゼブラフィッシュの展示、遺伝子導入法の紹介
[Notes] 理学部A棟1階エントランスホール、11月14日約50名、15日約100名
[3]. event 第5回キャンパスフェスタin静岡 静大オリジナルマウス系統 テラトーマ原因遺伝子に迫る (2015/11 )
[Details] 特殊なマウス系統が静岡大学で飼育維持され研究に活用されていることを一般の方にも理解してもらえるよう企画
[Notes] 理学部A棟1階エントランスホール、11月14日約10名、15日約20名
[4]. event 第4回キャンパスフェスタin静岡 モデル魚類ゼブラフィッシュと触れ合おう (2014/11 )
[Details] 研究材料として世界的に用いられているゼブラフィッシュの展示、遺伝子導入法の紹介
[Notes] 理学部A棟1階エントランスホール、11月15日約50名、16日約100名
[5]. extramural lecture ひらめきときめきサイエンス 「遺伝子操作をやってみる-光るサカナの作り方,使い方」 (2014/8 )
[Details] 中高生向けの実験講座
[Notes] 参加人数約20名、大谷総合研究棟625室
【News coverage】
[1]. newspaper 性差意識した研究発表 (2024/3/15)
[Notes] 静岡新聞朝刊16面
[2]. other 精巣性テラトーマの原因遺伝子を解明 -生殖細胞の分裂・分化制御メカニズムの解明に向けて- (2023/5/)
[Summary]移植実験による精巣性テラトーマの発症の原因遺伝子の一つがメラノコルチン4型受容体のミスセンス変異であることを証明した。
[Notes] PRTIMES
[3]. newspaper 湖は、いま 第4部ゆりかごの再生 研究室へ広がる熱意 (2021/8/31)
[Notes] 中日新聞朝刊27面
[4]. newspaper 魚類の生殖巣に悪影響 内分泌かく乱物質で4世代に (2018/9/20)
[Notes] 静岡新聞朝刊29面
[5]. TV 透明金魚 (2018/1/16)
[Notes] 静岡第一テレビ
【Committees outside the university, etc.】
[1]. 日本動物学会 国際交流委員会 (2014/4 ) [Association] 日本動物学会
[Details of activities]日本動物学会の国際化に向けた活動、国際学会の開催

International contributions

Others

【School dean, etc.】
[1]. 理学部生物科学科長 (2024/4 - 2025/3 )
[2]. 創造科学技術大学院 バイオサイエンス専攻長 (2023/4 )
[3]. 創造科学技術大学院 バイオサイエンス専攻長 (2022/4 )
[4]. 創造科学技術大学院 バイオサイエンス専攻長 (2021/4 )
[5]. 創造科学技術大学院 バイオサイエンス専攻長 (2020/4 )