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Researcher DataBase - Personal Information : TOKUMOTO Toshinobu

TOKUMOTO Toshinobu
Professor
College of Science - Division of Biological Science
Graduate School of Science and Technology,Research Division - Research of Integrated Bioscience
Faculty of Science - Department of Biological Science Graduate School of Integrated Science and Technology Department of Science - Biological Sciences Course

tokumoto.toshinobu@@@shizuoka.ac.jp
image-profile
Last updated : 2026/08/07 12:58:57

Basic information on teaching staff

【Degrees earned】
Doctor of Science  The Graduate University for Advanced Studies   1994/3
【research themes】
Analysis of molecular mechanism in oocyte maturation (meiotic cell cycle)
Non-genomic actions of steroids
【Research Keyword】
oocyte maturation, membrane steroid receptors, proteasome, ovulation, sex change
【Research Seeds】
[1]. ステロイド膜受容体の機能解明と創薬に向けた研究 ( 2019(FY) - ) [Category] 5. バイオ・ライフサイエンス [URL]
 

Research information

【Papers, etc.】
[1]. Membrane progestin receptors α and β (paqr7 and 8) are necessary for oogenesis in zebrafish
Zoological Science 43/4 - (2026) [Refereed] refereed [Internationally co-authored papers] internationally co-authored paper
[Lead author or co-author] author
[Author] Md. Almamun Farid, Md. Razain Tanvir, Takumi Mouri, Eisei Tsutsumi, Md Sohanur Rahman Sohan, Md. Ekramul Hasan, Md Saydur Rahman, Chihiro Yamamoto, Akiteru Maeno, Toshinobu Tokumoto [DOI]
[2]. Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill
Toxicology Mechanisms and Methods / - (2026) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Md Abul Bashar, Saokat Ahamed, Takumi Mouri, Md. Almamun Farid, Mohammad Maksudul Hassan, Yuna Uehara, Chihiro Yamamoto, Toshinobu Tokumoto [DOI]
[3]. Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina
Scientific Reports 16/ - 5988 (2026) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Mohammad Tohidul Amin, Shinya Kodani, Hiroyuki Nakagawa,Tomohiro Furukawa, Saokat Ahamed, Abdullah An Naser, Koki Yamaguchi, Yuki Omori, Shakhawat Hossain, Mohammad Maksudul Hassan, and Toshinobu Tokumoto [DOI]
[4]. Atrazine and diazinon inhibit oocyte maturation and ovulation in zebrafish
Reproductive Toxicology 140/ - 109172 (2026) [Refereed] refereed [Internationally co-authored papers] internationally co-authored paper
[Lead author or co-author] author
[Author] Md Hasan Ali, Maisum Sarwar Jyoti, Mrityunjoy Acharjee, Shakhawat Hossain, Saokat Ahamed, Md. Forhad Hossain & Toshinobu Tokumoto [DOI]
[5]. Establishment of an in vitro assay for analysis of the mechanism underlying chorion elevation in zebrafish
Zebrafish 22/6 218-222 (2025) [Refereed] refereed [Internationally co-authored papers] non-internationally co-authored paper
[Lead author or co-author] author
[Author] Eisei Tsutsumi, Toshinobu Tokumoto [DOI]
【Books, etc.】
[1].
(2024)
[Book type]other
[Sole author, co-author, or author and editor] single work
[Author]徳元俊伸 [REP page number] 1-9
[2]. Advances in Animal Science and Zoology
Nova Science Publishers (2023)
[Book type]book(research)
[Sole author, co-author, or author and editor] contributor
[Author]Md. Forhad Hossain, Toshinobu Tokumoto [Range] Is the Decrease in cAMP Concentration in Oocytes Really a Trigger for Oocyte Maturation Induction? - From the Perspective of Fish Research [Total page number] 21 [REP page number] 127-147
[3]. Understanding neuroendocrine regulatory pathways of sexual behavior in teleosts
Aquaculture and Fisheries (2023)
[Book type]book(research)
[Sole author, co-author, or author and editor] joint work
[Author]Saokat Ahamed and Toshinobu Tokumoto [REP page number] 1-8
[4]. Morphological and physiological studies on sex change in tropical fish: Sexual plasticity of the ovaries of hermaphroditic and gonochoristic fish
The Japanese Coral Reef Society (2022)
[Book type]other
[Sole author, co-author, or author and editor] joint work
[Author]Masaru Nakamura, Ryo Nozu, Shigeo Nakamura, Mikihiko Higa, Ramji K Bhandari, Yasuhisa Kobayashi, Ryo Horiguchi, Toru Komatsu, Yutaka Kojima, Ryosuke Murata, Kiyoshi Soyano, Satoshi Ogawa, Toshiaki Hirai, Hajime Matsubara, Toshinobu Tokumoto, Tohru Kobayashi, Hirohiko Kagawa, Shinji Adachi, Kohei Yamauchi, and Yoshitaka Nagahama [Total page number] 13
[Notes] Galaxea, Journal of Coral Reef Studies誌の総説
[5]. Membrane progestin receptor, a key mediator of final oocyte maturation in fish
NOVA Science Publishers Inc., USA (2018)
[Book type]book(research)
[Sole author, co-author, or author and editor] contributor
[Author]Toshinobu Tokumoto [Range] 423-440 [Total page number] 468 [REP page number] 423-440
【Academic conference/research presentations】
[1]. Phenotypic analysis of paqr genes knockout zebrafish
13th International Symposium on Reproductive Physiology of Fish (13th ISRPF) (2026/5/) other
[Presenter]Toshinobu Tokumoto
[Notes] Cairns, Australia
[2]. Sik1 is involved in the phosphorylation of actin proteins within the oocyte, and its inactivation causes abnormal arrangement of internal oocyte components, leading to developmental abnormalities
13th International Symposium on Reproductive Physiology of Fish (13th ISRPF) (2026/5/) other
[Presenter]Md. Ekramul Hasan· Md Sohanur Rahman· Shakhawat Hossain· Md. Saydur Rahman· Toshinobu Tokumoto
[Notes] Cairns, Australia
[3]. ゼブラフィッシュにおける排卵誘導遺伝子候補 ptgs2a ノックアウト系統の樹立
日本動物学会中部支部静岡大会 (2025/12/) other
[Presenter]上原優那, 毛利匠, Md Akib Ferdous, 堤瑛誠, Ekramul Hasan , 徳元俊伸
[Notes] 静岡大学理学部 日本動物学会中部支部静岡大会
[4]. Membrane progestin receptors α and β (paqr7 and 8) are necessary for oogenesis in zebrafish
日本動物学会中部支部静岡大会 (2025/12/) other
[Presenter]Md. Almamun Farid, Md. Razain Tanvir, Takumi Mouri, Eisei Tsutsumi, Md Sohanur Rahman Soha, Md. Ekramul Hasan, Md Saydur Rahman, Chihiro Yamamoto, Akiteru Maeno, Toshinobu Tokumoto
[Notes] 静岡大学理学部 日本動物学会中部支部静岡大会
[5]. Functional analysis of salt inducible Kinase 1 (sik1) in reproductive biology through CRISPR/Cas9 gene knockout technique
日本動物学会中部支部静岡大会 (2025/12/) other
[Presenter]Md. Ekramul Hasan, Md. Sohanur Rahman, Shakhawat Hossain, Md Saydur Rahman & Toshinobu Tokumoto
[Notes] 静岡大学理学部 日本動物学会中部支部静岡大会
【Joint or funded research】
[1]. funded (public) 構造活性相関に基づくステロイド膜受容体作用物質群の同定
leader ( 2009/4 ~ 2010/3 )
[Partners] 環境省
[Notes] ExTEND2005フィージビリティースタディー
[2]. funded (public) ステロイド膜受容体を標的とした化学物質の内分泌かく乱作用に関する研究
leader ( 2007/1 ~ 2009/3 )
[Partners] 環境省
[Notes] ExTEND2005フィージビリティースタディー
【Grants-in-aid for Scientific Research
[1]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2026/4 ~ 2029/3 ) Grant-in-Aid for Scientific Research (C) leader

[2]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2023/4 ~ 2026/3 ) Grant-in-Aid for Scientific Research (C) leader

[3]. ステロイド膜受容体の機能解析を中心とした卵成熟・排卵誘導機構の解明 ( 2020/4 ~ 2023/3 ) Grant-in-Aid for Scientific Research (C) leader

[4]. ステロイド膜受容体の機能・構造解析を中心とした卵成熟・排卵誘導機構の解明 ( 2016/4 ~ 2019/3 ) Grant-in-Aid for Scientific Research (C) leader

[5]. モーリシャスサンゴ礁海水中に存在する天然ホルモン活性物質の同定 ( 2015/4 ~ 2018/3 ) Grant-in-Aid for Scientific Research (B) leader

【Research Grants & Projects(except for KAKENHI)】
[1]. ノンゲノミック反応を伝達する新規ステロイド膜受容体の構造と機能に関する研究 (2010/3 ) [Offer orgnization] 財団法人 内藤記念科学振興財団 [System name] 内藤記念科学奨励金
[2]. ステロイド膜受容体の構造と機能に関する研究 (2008/9 ) [Offer orgnization] 財団法人サントリー生物有機科学研究所 [System name] SUNBOR GRANT
[3]. 卵成熟過程におけるプロテアソームの機能の解析 (1995/9 ) [Offer orgnization] 実吉奨学会 [System name] 研究助成金
【Patents, etc.】
[1]. コルチコイドに特異的に結合するタンパク質 [Application Number] 特願2025-128422 (2025/7/31)
[2]. プロゲスチン膜受容体の新規アンタゴニスト [Application Number] 特願2024-202123 (2024/11/20)
[3]. ステロイドホルモン膜受容体の精製方法 [Application Number] 特願2013-136980 (2013/6/28) [Patent Number] 特許第6516956号 (2019/4/26)
[Notes] 特開2015-10064
[4]. ステロイドホルモン膜受容体の精製方法 [Application Number] 特願2019-038776 (2013/6/28) [Patent Number] 特許第6516956号 (2020/11/16)
[5]. 内分泌撹乱性物質のスクリーニング方法 [Application Number] 特願2005-267894 (2005/9/15) [Patent Number] 特許第4528973号 (2010/6/18)
【Holding academic or research conferences, etc.】
[1]. 日本動物学会中部支部大会静岡大会 (2025/12)
[Role at conference, etc.] is leader [Site of conference, etc.] 静岡大学 理学部
[Notes] 参加者は、現地会場が233名、オンラインが30名 https://www.zoology.or.jp/archives/news/news-6894
[2]. Sustainability & Technology Workshop 2025 (2025/8)
[Role at conference, etc.] is leader [Site of conference, etc.] 静岡大学 理学部
[Notes] 国費留学生優先配置特別プログラム主催のワークショップ 2025年テーマ Bioscience for Sustainable Development: Advancing Knowledge and Action
[3]. Sustainability & Technology Workshop 2024 (2024/8)
[Role at conference, etc.] is leader [Site of conference, etc.] 静岡大学 理学部
[Notes] 国費留学生優先配置特別プログラム主催のワークショップ 2024年テーマ Bioscience for Sustainable Development: Advancing Knowledge and Action
[4]. Sustainability & Technology Workshop 2023 (2023/8)
[Role at conference, etc.] is leader [Site of conference, etc.] 静岡大学 理学部
[Notes] 国費留学生優先配置特別プログラム主催のワークショップ 2023年テーマ Bioscience for Sustainable Development: Advancing Knowledge and Action
[5]. 「ナノバイオロジー」への招待 日本動物学会 シンポジウム (2009/9)
[Role at conference, etc.] is leader [Site of conference, etc.] グランシップ 静岡市 
[Notes] 日本動物学会年次大会におけるシンポジウムの主催

Education related information

【Courses being taught this academic year】
[1]. Graduate School Course(Master's) 生物科学特別論文演習Ⅰ (2026(FY) - full year )
[Notes] 副担当
[2]. Graduate School Course(Master's) 生物科学特別論文演習Ⅱ (2026(FY) - full year )
[Notes] 副担当
[3]. Faculty Course 生物学実験 (2026(FY) - first semester )
[Notes] 副担当
[4]. Graduate School Course(Master's) 創造科学技術先端機器分析演習Ⅱ (2026(FY) - second semester )
[5]. Graduate School Course(Master's) 創造科学技術入門セミナーⅡ (2026(FY) - first semester )
[Notes] 副担当
【Number of students advising】
2024(FY)
Number of undergraduate students(junior students) 4
Number of undergraduate students(senior students) 2
Number of master's course students : 4
Number of doctorate course students (main advisor) : 12 Number of doctorate course students (assistant advisor) : 1
2023(FY)
Number of undergraduate students(junior students) 3
Number of undergraduate students(senior students) 2
Number of master's course students : 7
Number of doctorate course students (main advisor) : 12 Number of doctorate course students (assistant advisor) : 2
2022(FY)
Number of undergraduate students(junior students) 4
Number of undergraduate students(senior students) 3
Number of master's course students : 6
Number of doctorate course students (main advisor) : 8 Number of doctorate course students (assistant advisor) : 2
2021(FY)
Number of undergraduate students(senior students) 4
Number of master's course students : 7
Number of doctorate course students (main advisor) : 7 Number of doctorate course students (assistant advisor) : 2
2020(FY)
Number of undergraduate students(senior students) 3
Number of master's course students : 6
Number of doctorate course students (main advisor) : 7 Number of doctorate course students (assistant advisor) : 2
【Prizes students you are advising won】
[1]. 創造科学技術大学院 院長表彰 (2024/9)
[Name of student who received the prize] Md. Forhad Hossain (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 創造科学技術大学院
[2]. Best Presentation Award (2024/3)
[Name of student who received the prize] Md. Forhad Hossain (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 2024 The10th International Symposium toward the Future of Advanced Researches in Shizuoka University (ISFAR-SU2024)
[3]. The Best Presentation Award For Young Researchers (2023/9)
[Name of student who received the prize] Mohammad Maksudul Hassan (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 第20回Inter-Academia 2023
[4]. Best Presentation Award (2021/3)
[Name of student who received the prize] Theeranukul Pachoensuk (Graduate School of Science and Technology, Educational Division)
[Name of organization that offered the prize] 2021 The 7th International Symposium toward the Future of Advanced Researches in Shizuoka University (ISFAR-SU2021)
[5]. 優秀ポスター賞 (2019/3)
[Name of student who received the prize] 平野里沙 (Faculty of Science)
[Name of organization that offered the prize] 第20回静岡ライフサイエンスシンポジウム 静岡生命科学若手フォーラム主催
【Information education-related information.】
[1]. 科学技術振興機構 中高生の科学部活動振興プログラム 「静岡県遠州南部地域のクマムシ調査」掛川西高校  (2013/4 - 2015/3 )
[2]. 理数学生応援プロジェクト 「主体性を伸ばす理数特別カリキュラムによる科学者養成プログラム」の申請、採択後の運営 (2009/1 - 2013/1 )

Contributions to society

【Seminar,Workshop, Event, etc.】
[1]. event ライフサイエンスワールド2016 (2016/5 - 2016/5 )
[Details] 「活性型・ヒト型プロゲステロン膜受容体(mPR)の大量合成技術を確立」という題目で新技術に関する講演、ブースの出展を行った。
[Notes] 東京ビッグサイトにて
[2]. event 第5回キャンパスフェスタin静岡 モデル魚類ゼブラフィッシュと触れ合おう (2015/11 )
[Details] 研究材料として世界的に用いられているゼブラフィッシュの展示、遺伝子導入法の紹介
[Notes] 理学部A棟1階エントランスホール、11月14日約50名、15日約100名
[3]. event 第5回キャンパスフェスタin静岡 静大オリジナルマウス系統 テラトーマ原因遺伝子に迫る (2015/11 )
[Details] 特殊なマウス系統が静岡大学で飼育維持され研究に活用されていることを一般の方にも理解してもらえるよう企画
[Notes] 理学部A棟1階エントランスホール、11月14日約10名、15日約20名
[4]. event 第4回キャンパスフェスタin静岡 モデル魚類ゼブラフィッシュと触れ合おう (2014/11 )
[Details] 研究材料として世界的に用いられているゼブラフィッシュの展示、遺伝子導入法の紹介
[Notes] 理学部A棟1階エントランスホール、11月15日約50名、16日約100名
[5]. extramural lecture ひらめきときめきサイエンス 「遺伝子操作をやってみる-光るサカナの作り方,使い方」 (2014/8 )
[Details] 中高生向けの実験講座
[Notes] 参加人数約20名、大谷総合研究棟625室
【News coverage】
[1]. other プロゲステロン膜受容体の新規拮抗物質を同定― 新規医薬品候補の発見 ― (2026/1/26)
[Notes] 静岡大学プレスリリース、PRTIMESを通した複数のWebニュースへの掲載
[2]. other エストロゲン膜受容体の人工合成と反応物質検出系の確立― 新規医薬品の発見に向けて ― (2025/9/18)
[Notes] 静岡大学プレスリリース、PRTIMESを通した複数のWebニュースへの掲載
[3]. other プロゲステロン膜受容体(rタイプ)は魚類嗅神経の形成に必須であることを解明しました (2024/10/)
[Notes] 国立遺伝学研究所プレスリリース、静岡大学プレスリリース、PRTIMESを通した複数のWebニュースへの掲載
[4]. newspaper ★ゲノム編集で透明な金魚、静岡大が開発 (2024/8/18)
[Notes] 静岡新聞朝刊9面
[5]. newspaper 性差意識した研究発表 (2024/3/15)
[Notes] 静岡新聞朝刊16面
【Committees outside the university, etc.】
[1]. 日本動物学会 国際交流委員会 (2014/4 ) [Association] 日本動物学会
[Details of activities]日本動物学会の国際化に向けた活動、国際学会の開催

International contributions

Others

【School dean, etc.】
[1]. 理学部生物科学科長 (2024/4 - 2025/3 )
[2]. 創造科学技術大学院 バイオサイエンス専攻長 (2023/4 )
[3]. 創造科学技術大学院 バイオサイエンス専攻長 (2022/4 - 2024/3 )
[4]. 創造科学技術大学院 バイオサイエンス専攻長 (2021/4 - 2022/3 )
[5]. 創造科学技術大学院 バイオサイエンス専攻長 (2020/4 - 2021/3 )